I-FISH Providers
Specific chromosomal aberrations, i.e., 3q gains/7q losses, may precede and herald the development of myelodysplastic syndrome and leukaemia. Interphase fluorescent in situ hybridisation (I-FISH) should be used to screen for such aberrations on both peripheral blood and bone marrow cell samples on FA affected individuals who have not undergone a haematopoietic stem cell transplant (and that may be otherwise missed by conventional cytogenetic analysis). For further information on I-FISH in FA, see Section 6 of the UK FA Standards of Care document.
There are currently two regional NHS cytogenetic laboratories in the UK providing I-FISH in FA:
Dr Edna Maltby
Sheffield Regional Cytogenetics Service
Sheffield Children’s Hospital NHS Foundation Trust
Western Bank
Sheffield
S10 2TH
Tel 0114 2717000
and
Dr Mike Griffiths
West Midlands Regional Cytogenetics Service
Birmingham Women’s Hospital NHS Foundation Trust
Metchley Park Road
Edgbaston
Birmingham
B15 2TG
Tel 0121 6272710
